Nature Communications (Feb 2022)

Pluripotency factors determine gene expression repertoire at zygotic genome activation

  • Meijiang Gao,
  • Marina Veil,
  • Marcus Rosenblatt,
  • Aileen Julia Riesle,
  • Anna Gebhard,
  • Helge Hass,
  • Lenka Buryanova,
  • Lev Y. Yampolsky,
  • Björn Grüning,
  • Sergey V. Ulianov,
  • Jens Timmer,
  • Daria Onichtchouk

DOI
https://doi.org/10.1038/s41467-022-28434-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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Zygotic genome activation in zebrafish relies on pluripotency transcription factors Pou5f3 and Sox19b. Here the authors investigate how these factors interact in vivo by analyzing the changes in chromatin state and time-resolved transcription in Pou5f3 and Sox19b single and double mutant embryos.