Emerging Infectious Diseases (Feb 2021)

Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam

  • Huynh Kim Mai,
  • Nguyen Bao Trieu,
  • Trinh Hoang Long,
  • Hoang Tien Thanh,
  • Nguyen Dinh Luong,
  • Le Xuan Huy,
  • Lam Anh Nguyet,
  • Dinh Nguyen Huy Man,
  • Danielle E. Anderson,
  • Tran Tan Thanh,
  • Nguyen Van Vinh Chau,
  • Guy Thwaites,
  • Lin-Fa Wang,
  • Le Van Tan,
  • Do Thai Hung

DOI
https://doi.org/10.3201/eid2702.204226
Journal volume & issue
Vol. 27, no. 2
pp. 663 – 666

Abstract

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Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18–30 after diagnosis, all remained seropositive but spike protein–targeting antibody titers declined. These data may be useful for vaccine development.

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