Neutrophil Extracellular Traps in Airway Diseases: Pathological Roles and Therapeutic Implications

Abstract

Neutrophils are important effector cells of the innate immune response that fight pathogens by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into the extracellular space to defend against invading pathogens. Although NETs play a defensive role against pathogens, excessive NETs can contribute to the pathogenesis of airway diseases. NETs are known to be directly cytotoxic to the lung epithelium and endothelium, highly involved in acute lung injury, and implicated in disease severity and exacerbation. This review describes the role of NET formation in airway diseases, including chronic rhinosinusitis, and suggests that targeting NETs could be a therapeutic strategy for airway diseases.

Keywords

• neutrophil extracellular traps
• therapeutic targets
• airway diseases
• asthma
• chronic rhinosinusitis
• cystic fibrosis