Diabetes, Metabolic Syndrome and Obesity (Dec 2023)
The Correlation Between Leg Muscle Mass Index and Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
Abstract
Menggege Liu,1,2 Qing Zhang,1,3 Juan Liu,1 Huiling Bai,1 Ping Yang,1 Xinhua Ye,1,3 Xiaoqing Yuan1,3 1Department of Endocrinology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 2Second Clinical College, Dalian Medical University, Dalian, People’s Republic of China; 3Changzhou Medical Center, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Xiaoqing Yuan; Xinhua Ye, Email [email protected]; [email protected]: To analyze the relationship between leg skeletal muscle mass index (LSMI) and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) and the ability of LSMI to predict NAFLD.Methods: Two hundred patients with T2DM and NAFLD treated at Changzhou Second People’s Hospital Affiliated with Nanjing Medical University and the National Metabolic Management Center from June 2022 to June 2023 were divided into four LSMI quartiles. The clinical information from the four patient groups was compared, and the relationship between type 2 diabetes and LSMI and NAFLD was examined. We used receiver operating characteristic curves to determine how well the LSMI predicts NAFLD in T2DM.Results: The lowest quartile (Q1) had a higher prevalence of NAFLD than group Q4 (P < 0.05). LSMI was negatively associated with body mass index, LS, CAP, and other markers (P < 0.05). Receiver operating characteristic curve analysis LSMI predicted NAFLD with an ideal critical value of 0.64 and an area under the curve of 70.9%. The combined predictive value of the LSMI and the appendicular skeletal muscle mass index was more significant.Conclusion: Reduced LSMI is associated with NAFLD.Keywords: non-alcoholic fatty liver disease, type 2 diabetes mellitus, LSMI, ASMI
