Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion

Anna Gorelick-Ashkenazi; Ron Weiss; Lena Sapozhnikov; Anat Florentin; Lama Tarayrah-Ibraheim; Dima Dweik; Keren Yacobi-Sharon; Eli Arama

doi:10.1038/s41467-018-05204-6

Nature Communications (Jul 2018)

Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion

Anna Gorelick-Ashkenazi,
Ron Weiss,
Lena Sapozhnikov,
Anat Florentin,
Lama Tarayrah-Ibraheim,
Dima Dweik,
Keren Yacobi-Sharon,
Eli Arama

Affiliations

Anna Gorelick-Ashkenazi: Department of Molecular Genetics, Weizmann Institute of Science
Ron Weiss: Department of Molecular Genetics, Weizmann Institute of Science
Lena Sapozhnikov: Department of Molecular Genetics, Weizmann Institute of Science
Anat Florentin: Department of Molecular Genetics, Weizmann Institute of Science
Lama Tarayrah-Ibraheim: Department of Molecular Genetics, Weizmann Institute of Science
Dima Dweik: Department of Molecular Genetics, Weizmann Institute of Science
Keren Yacobi-Sharon: Department of Molecular Genetics, Weizmann Institute of Science
Eli Arama: Department of Molecular Genetics, Weizmann Institute of Science

DOI: https://doi.org/10.1038/s41467-018-05204-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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In addition to regulating programmed cell death, caspases also have non-apoptotic roles. Here, the authors show that low level caspase activity prevents cell migration to maintain tissue integrity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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