Uric acid, gout and cardiovascular diseases: prospects for the use of urat-lowering medications

Abstract

A large number of studies conducted throughout the world showed that gout and hyperuricemia were independent predictors of a high risk for the development of comorbid pathology, including cardiovascular lesions.Hyperuricemia is associated with all metabolic syndrome components, such as lipid storage disease, high body mass index, arterial hypertension, glucose metabolism disorders. On the other hand, in addition to the high level of uric acid, gout is characterized by chronic inflammation; the combined effect of these factors has a pathological effect on the vascular bed and is an additional risk factor for the development of atherosclerosis and associated diseases.This article discusses the possible mechanisms of influence of uric acid levels and gout on the development of cardiovascular pathology, and provides an analysis of works demonstrating the beneficial effect of urate-lowering therapy on outcomes.

Keywords

• gout
• hyperuricemia
• uric acid
• cardiovascular disease
• febuxostat
• allopurinol