Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies

M. Selim; Hamouda M. Mousa; Muhammad Umar Aslam Khan; Gamal T. Abdel-Jaber; Nabisab Mujawar Mubarak; Ahmed Barhoum; Abdulaziz Al-Anazi; Abdalla Abdal-hay

Journal of Science: Advanced Materials and Devices (Dec 2024)

Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies

M. Selim,
Hamouda M. Mousa,
Muhammad Umar Aslam Khan,
Gamal T. Abdel-Jaber,
Nabisab Mujawar Mubarak,
Ahmed Barhoum,
Abdulaziz Al-Anazi,
Abdalla Abdal-hay

Affiliations

M. Selim: Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt
Hamouda M. Mousa: Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt; Faculty of Technological Industry and Energy, Thebes Technological University, Thebes, Luxor, 85863, Egypt
Muhammad Umar Aslam Khan: Department of Mechanical and Industrial Engineering, Qatar University, Doha, 2713, Qatar; Biomedical Research Center, Qatar University, Doha, 2713, Qatar
Gamal T. Abdel-Jaber: Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt
Nabisab Mujawar Mubarak: Petroleum and Chemical Engineering, Faculty of Engineering, Universiti Teknologi Brunei, Bandar Seri Begawan, BE1410, Brunei Darussalam; Department of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Jalandhar, Punjab, India; Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India
Ahmed Barhoum: NanoStruc Research Group, Chemistry Department, Faculty of Science, Helwan University, Cairo, 11795, Egypt
Abdulaziz Al-Anazi: Department of Chemical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh, 11421, Saudi Arabia; Corresponding author.
Abdalla Abdal-hay: Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt; School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia; Centre for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3), Herston, QLD, 4006, Australia; Corresponding author. Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt.

Journal volume & issue: Vol. 9, no. 4
p. 100806

Abstract

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Bone tissue engineering holds promise for addressing bone injuries by using biomaterial-based 3D scaffolds. The efficacy of these scaffolds is paramount, relying heavily on their ability to interact with cells and facilitate tissue regeneration. This comprehensive review delves into various modification and functionalization strategies to enhance the performance of biomaterial 3D scaffolds in bone tissue engineering. The review encompasses a wide range of techniques, including physical methods such as surface roughening and patterning, and chemical modifications like plasma treatment and functional group grafting. Additionally, surface-coating approaches employing biomolecules and nanoparticles are explored. Synthesizing current research findings offers valuable insights into optimizing biomaterial scaffolds for effective bone tissue regeneration applications. In addition, discussions encompass the influence of scaffold morphology, mechanical properties, and degradation kinetics on cellular responses and tissue integration. By thoroughly examining these strategies, future research will be guided toward developing advanced biomaterial scaffolds tailored specifically for bone tissue engineering applications.

Published in Journal of Science: Advanced Materials and Devices

ISSN: 2468-2284 (Print); 2468-2179 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/journal-of-science-advanced-materials-and-devices

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