Prognosis of very preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension and patent ductus arteriosus: An analysis of 9 cases

Abstract

Objective To investigate the clinical outcome of 9 very preterm infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) and patent ductus arteriosus (PDA) after PDA ligation. Methods A retrospective analysis was performed for the clinical data of 9 very preterm infants with BPD-associated PH and PDA, and all infants underwent PDA ligation and were followed up regularly after surgery. Results After surgical treatment, 7 infants had normal pulmonary artery pressure and were discharged after successful ventilator weaning, and all these infants were regularly followed up to June 2022 at the outpatient service, among whom the oldest infant was aged 4 years; echocardiography showed that all infants had normal heart structure and function, pulmonary artery pressure, and growth and development, without recurrent respiratory infection. Two infants died. Conclusion Very preterm infants with BPD-associated PH and PDA often have critical situations, and in case of failed pharmacotherapy, timely PDA ligation is an important method to improve prognosis.

Keywords

• bronchopulmonary dysplasia|ductus arteriosus, patent|pulmonary arterial hypertension|ligation|prognosis|infant, extremely premature