Ultrasound‐Activated Piezoelectric MoS2 Enhances Sonodynamic for Bacterial Killing
Chaofeng Wang,
Wenchan Sun,
Yiming Xiang,
Shuilin Wu,
Yufeng Zheng,
Yu Zhang,
Jie Shen,
Lei Yang,
Chunyong Liang,
Xiangmei Liu
Affiliations
Chaofeng Wang
School of Life Science and Health Engineering Hebei University of Technology Xiping Avenue 5340 Tianjin 300401 China
Wenchan Sun
Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science & Engineering Hubei University Wuhan 430062 China
Yiming Xiang
Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science & Engineering Hubei University Wuhan 430062 China
Shuilin Wu
School of Materials Science & Engineering Peking University Yiheyuan Road 5# Beijing 100871 China
Yufeng Zheng
School of Materials Science & Engineering Peking University Yiheyuan Road 5# Beijing 100871 China
Yu Zhang
Department of Orthopedics Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Zhongshan 2nd Road 106# Guangzhou 510080 China
Jie Shen
Shenzhen Key Laboratory of Spine Surgery Department of Spine Surgery Peking University Shenzhen Hospital Lianhua Road 1120#, Futian District Shenzhen 518036 China
Lei Yang
School of Life Science and Health Engineering Hebei University of Technology Xiping Avenue 5340 Tianjin 300401 China
Chunyong Liang
School of Life Science and Health Engineering Hebei University of Technology Xiping Avenue 5340 Tianjin 300401 China
Xiangmei Liu
School of Life Science and Health Engineering Hebei University of Technology Xiping Avenue 5340 Tianjin 300401 China
Bacterial infections are a serious public health issue that threatens the lives of patients because of their ability to induce other lethal complications without prompt treatment. Conventional antibiotic therapy can cause bacterial resistance and other adverse effects. It is highly desirable to develop effective and antibiotic‐independent therapeutic strategies to treat various kinds of bacterial infections. Herein, sonodynamic‐enhanced piezoelectric materials MoS2 and Cu2Oheterostructure that responds to exogenous ultrasound (US) and generates reactive oxygen for Staphylococcus aureus elimination are developed. It is shown in the results that the polariton charge induced by piezoelectric MoS2 nanosheets under US irradiation can accelerate the transfer of electric in Cu2O. Furthermore, US irradiation induces valence conversion from Cu(I) to Cu(II), which can accelerate glutathione oxidation significantly and destroy the bacterial antioxidant defense system. Hence, the as‐prepared piezoelectric‐enhanced sonosensitizer possesses a highly effective antibacterial efficacy of 99.85% against S. aureus under US irradiation for 20 min, with good biocompatibility. Herein, effective ultrasonic piezocatalytic therapy is offered through constructing heterogeneous interfaces with ultrasonic piezoelectric response.
