Nature Communications (May 2017)

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy

  • Fang Wang,
  • Cheng Xu,
  • E. Albert Reece,
  • Xuezheng Li,
  • Yanqing Wu,
  • Christopher Harman,
  • Jingwen Yu,
  • Daoyin Dong,
  • Cheng Wang,
  • Penghua Yang,
  • Jianxiang Zhong,
  • Peixin Yang

DOI
https://doi.org/10.1038/ncomms15182
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Maternal diabetes can induce neural tube defects (NTD). Here, the authors show that in mice, deletion ofPrkca(encoding protein kinase C-alpha) restores autophagy, via suppression of miR-129-2 and reversal of reduced peroxisome proliferator-activated receptor c coactivator 1alpha, so reducing NTDs.