Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers
Christopher J. Stefan,
William S. Trimble,
Sergio Grinstein,
Guillaume Drin,
Karin Reinisch,
Pietro De Camilli,
Sarah Cohen,
Alex M. Valm,
Jennifer Lippincott-Schwartz,
Tim P. Levine,
David B. Iaea,
Frederick R. Maxfield,
Clare E. Futter,
Emily R. Eden,
Delphine Judith,
Alexander R. van Vliet,
Patrizia Agostinis,
Sharon A. Tooze,
Ayumu Sugiura,
Heidi M. McBride
Affiliations
Christopher J. Stefan
MRC Laboratory for Molecular Cell Biology, University College London
William S. Trimble
Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto
Sergio Grinstein
Cell Biology Program, The Hospital for Sick Children and Department of Biochemistry, University of Toronto
Guillaume Drin
Université Côte d’Azur, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire
Karin Reinisch
Department of Cell Biology, Yale University School of Medicine
Pietro De Camilli
Department of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Kavli Institute for Neuroscience and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine
Sarah Cohen
NICHD, NIH
Alex M. Valm
NICHD, NIH
Jennifer Lippincott-Schwartz
HHMI Janelia Research Campus
Tim P. Levine
UCL Institute of Ophthalmology
David B. Iaea
Genentech
Frederick R. Maxfield
Department of Biochemistry, Weill Cornell Medical College
Clare E. Futter
UCL Institute of Ophthalmology
Emily R. Eden
UCL Institute of Ophthalmology
Delphine Judith
Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute
Alexander R. van Vliet
Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute
Patrizia Agostinis
Laboratory of Cell Death Research and Therapy, Department of Cellular and Molecular Medicine, KU Leuven
Sharon A. Tooze
Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute
Ayumu Sugiura
Kobe University Graduate School of Medicine
Heidi M. McBride
Montreal Neurological Institute, McGill University
Abstract Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.
