Association of impaired fasting glucose with cardiometabolic multimorbidity: The Kailuan study

Abstract

Abstract Aims/Introduction We investigated the association between impaired fasting glucose (IFG) and cardiometabolic multimorbidity (CMM) in the Chinese population. Materials and Methods We included 119,368 participants, free of diabetes mellitus and cardiovascular disease, who participated in the health examination (2006, 2008, 2010) of the Kailuan Study. According to World Health Organization diagnostic criteria, participants were divided into normal fasting blood glucose (FBG) (1.25 (95% CI 1.13–1.37) for myocardial infarction, 1.16 (95% CI 1.07–1.25) for ischemic stroke and 1.06 (95% CI 0.88–1.27) for hemorrhagic stroke. Compared with normal FBG, HRs for risk of IFG for CMM were 2.73 (95% CI 2.48–3.02) in men and 3.86 (95% CI 2.92–5.09) in women. Conclusion IFG was a risk factor for CMM. The effect of IFG on diabetes mellitus was stronger than that on other cardiometabolic diseases. The effects of IFG for CMM differed by sex.

Keywords

• Cardiometabolic multimorbidity
• Cardiovascular diseases
• Impaired fasting glucose