Ciência Animal Brasileira (Sep 2011)

ATIVIDADE DA LACTATO DESIDROGENASE (LDH) SÉRICA EM CÃES SUBMETIDOS À OXIGENAÇÃO EXTRACORPÓREA POR MEMBRANA (ECMO) POR UM PERÍODO DE TRÊS HORAS

  • FELIPP SILVEIRA FERREIRA,
  • LARA LAGES SILVEIRA,
  • ALESSANDRA CASTELLO COSTA,
  • DANIELA FANTINI VALE,
  • CLAUDIO BAPTISTA CARVALHO,
  • JOSIAS ALVES MACHADO,
  • ANDRÉ LACERDA DE ABREU OLIVEIRA

Journal volume & issue
Vol. 12, no. 3
pp. 554 – 559

Abstract

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The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior oflactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH,featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.

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