Nature Communications (Jun 2018)

Molecular basis of Tousled-Like Kinase 2 activation

  • Gulnahar B. Mortuza,
  • Dario Hermida,
  • Anna-Kathrine Pedersen,
  • Sandra Segura-Bayona,
  • Blanca López-Méndez,
  • Pilar Redondo,
  • Patrick Rüther,
  • Irina Pozdnyakova,
  • Ana M. Garrote,
  • Inés G. Muñoz,
  • Marina Villamor-Payà,
  • Cristina Jauset,
  • Jesper V. Olsen,
  • Travis H. Stracker,
  • Guillermo Montoya

DOI
https://doi.org/10.1038/s41467-018-04941-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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The Tousled-like kinase (TLKs) family belongs to a distinct branch of Ser/Thr kinases that exhibit the highest levels of activity during DNA replication. Here the authors present the crystal structure of the kinase domain from human TLK2 and propose an activation model for TLK2 based on biochemical and phosphoproteomics experiments.