Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis

Abstract

Liver injury: Citrus peel to the rescue Nobiletin, an antioxidant found in citrus peel, may protect the liver from reperfusion injury, damage following blood flow interruption. When blood flow is restricted and then restored, as in transplant, surgery, or shock, cells are injured, largely due to damage to the cellular powerhouses, the mitochondria. Nobiletin is known to have many benefits, including anti-cancer and anti-inflammatory activities, but its mechanism of action is not well understood. Sang Won Park and Hwajin Kim, at the Gyeongsang National University School of Medicine, in Jinju, South Korea, and co-workers, investigated how nobiletin might protect the liver against interruption of blood flow. They found that nobiletin triggered cells to dismantle damaged mitochondria and produce new, functioning mitochondria, greatly reducing liver damage. These results illuminate how nobiletin works and may lead to better treatments for liver reperfusion injury.