Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery

Chaoxiang Chen; Jialin Wang; Mengdi Sun; Jian Li; Hui-Min David Wang

Biomedicine & Pharmacotherapy (Jan 2022)

Toward the next-generation phyto-nanomedicines: cell-derived nanovesicles (CDNs) for natural product delivery

Chaoxiang Chen,
Jialin Wang,
Mengdi Sun,
Jian Li,
Hui-Min David Wang

Affiliations

Chaoxiang Chen: College of Food and Biological Engineering, Jimei University, China
Jialin Wang: College of Food and Biological Engineering, Jimei University, China
Mengdi Sun: College of Food and Biological Engineering, Jimei University, China
Jian Li: College of Food and Biological Engineering, Jimei University, China; Correspondence to: College of Food and Biological Engineering, Jimei University, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Xiamen 361021, China.
Hui-Min David Wang: Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung City 404, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Correspondence to: Graduate Institute of Biomedical Engineering, National Chung Hsing University, No.145, Xingda Rd., South Dist., Taichung City 402, Taiwan.

Journal volume & issue: Vol. 145
p. 112416

Abstract

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Phytochemicals are plant-derived bioactive compounds, which have been widely used for therapeutic purposes. Due to the poor water-solubility, low bioavailability and non-specific targeting characteristic, diverse classes of nanocarriers are utilized for encapsulation and delivery of bio-effective agents. Cell-derived nanovesicles (CDNs), known for exosomes or extracellular vesicles (EVs), are biological nanoparticles with multiple functions. Compared to the artificial counterpart, CDNs hold great potential in drug delivery given the higher stability, superior biocompatibility and the lager capability of encapsulating bioactive molecules. Here, we provide a bench-to-bedside review of CDNs-based nanoplatform, including the bio-origin, preparation, characterization and functionalization. Beyond that, the focus is laid on the therapeutic effect of CDNs-mediated drug delivery for natural products. The state-of-art development as well as some pre-clinical applications of using CDNs for disease treatment is also summarized. It is highly expected that the continuing development of CDNs-based delivery systems will further promote the clinical utilization and translation of phyto-nanomedicines.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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