MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

Atsushi Sakai; Fumihito Saitow; Motoyo Maruyama; Noriko Miyake; Koichi Miyake; Takashi Shimada; Takashi Okada; Hidenori Suzuki

doi:10.1038/ncomms16079

Nature Communications (Jul 2017)

MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

Atsushi Sakai,
Fumihito Saitow,
Motoyo Maruyama,
Noriko Miyake,
Koichi Miyake,
Takashi Shimada,
Takashi Okada,
Hidenori Suzuki

Affiliations

Atsushi Sakai: Department of Pharmacology, Nippon Medical School
Fumihito Saitow: Department of Pharmacology, Nippon Medical School
Motoyo Maruyama: Department of Pharmacology, Nippon Medical School
Noriko Miyake: Department of Biochemistry and Molecular Biology, Nippon Medical School
Koichi Miyake: Department of Biochemistry and Molecular Biology, Nippon Medical School
Takashi Shimada: Department of Biochemistry and Molecular Biology, Nippon Medical School
Takashi Okada: Department of Biochemistry and Molecular Biology, Nippon Medical School
Hidenori Suzuki: Department of Pharmacology, Nippon Medical School

DOI: https://doi.org/10.1038/ncomms16079
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Dysregulation of voltage gated potassium channels is a feature of neuropathic pain. Here in a rat model the authors identify the microRNA cluster miR-17-92 as a regulator of voltage gated potassium channels in the dorsal root ganglion neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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