BDMC protects AD in vitro via AMPK and SIRT1

Abstract

Alzheimer’s disease (AD) is a common neurodegenerative disorder without any satisfactory therapeutic approaches. AD is mainly characterized by the deposition of β-amyloid protein (Aβ) and extensive neuronal cell death. Curcumin, with anti-oxidative stress (OS) and cell apoptosis properties, plays essential roles in AD. However, whether bisdemethoxycurcumin (BDMC), a derivative of curcumin, can exert a neuroprotective effect in AD remains to be elucidated.

Keywords

• alzheimer’s disease (ad)
• bisdemethoxycurcumin (bdmc)
• ampk
• sirt1