Communications Biology (Sep 2022)

The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase

George Khelashvili,
Ekaterina Kots,
Xiaolu Cheng,
Michael V. Levine,
Harel Weinstein

Affiliations

George Khelashvili: Department of Physiology and Biophysics, Weill Cornell Medicine
Ekaterina Kots: Department of Physiology and Biophysics, Weill Cornell Medicine
Xiaolu Cheng: Department of Physiology and Biophysics, Weill Cornell Medicine
Michael V. Levine: Department of Physiology and Biophysics, Weill Cornell Medicine
Harel Weinstein: Department of Physiology and Biophysics, Weill Cornell Medicine

DOI: https://doi.org/10.1038/s42003-022-03930-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

Molecular dynamics simulations reveal the allosteric mechanism leading to an open, lipid scrambling competent state of a mammalian TMEM16F.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal