Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene‐edited human‐induced pluripotent stem cell‐derived cardiomyocytes and preclinical drug screening

• Ibrahim El‐Battrawy,
• Huan Lan,
• Lukas Cyganek,
• Lasse Maywald,
• Rujia Zhong,
• Feng Zhang,
• Qiang Xu,
• Jihyun Lee,
• Eliane Duperrex,
• Andreas Hierlemann,
• Ardan M. Saguner,
• Firat Duru,
• Boldizsar Kovacs,
• Mengying Huang,
• Zhenxing Liao,
• Sebastian Albers,
• Jonas Müller,
• Hendrik Dinkel,
• Lena Rose,
• Alyssa Hohn,
• Zhen Yang,
• Lin Qiao,
• Yingrui Li,
• Siegfried Lang,
• Mandy Kleinsorge,
• Andreas Mügge,
• Assem Aweimer,
• Xuehui Fan,
• Sebastian Diecke,
• Ibrahim Akin,
• Guang Li,
• Xiaobo Zhou

Affiliations

Ibrahim El‐Battrawy

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Huan Lan

Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province Institute of Cardiovascular Research, Southwest Medical University Luzhou China

Lukas Cyganek

Stem Cell Unit, Clinic for Cardiology and Pneumology University Medical Center Göttingen Göttingen Germany

Lasse Maywald

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Rujia Zhong

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Feng Zhang

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Qiang Xu

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Jihyun Lee

Department of Biosystems Science and Engineering Bioengineering Laboratory Basel Switzerland

Eliane Duperrex

Department of Biosystems Science and Engineering Bioengineering Laboratory Basel Switzerland

Andreas Hierlemann

Department of Biosystems Science and Engineering Bioengineering Laboratory Basel Switzerland

Ardan M. Saguner

Department of Cardiology Electrophysiology Division University Heart Center Zurich Zurich Switzerland

Firat Duru

Department of Cardiology Electrophysiology Division University Heart Center Zurich Zurich Switzerland

Boldizsar Kovacs

Department of Cardiology Electrophysiology Division University Heart Center Zurich Zurich Switzerland

Mengying Huang

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Zhenxing Liao

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Sebastian Albers

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Jonas Müller

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Hendrik Dinkel

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Lena Rose

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Alyssa Hohn

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Zhen Yang

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Lin Qiao

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Yingrui Li

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Siegfried Lang

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Mandy Kleinsorge

Stem Cell Unit, Clinic for Cardiology and Pneumology University Medical Center Göttingen Göttingen Germany

Andreas Mügge

Department of Cardiology and Angiology Bergmannsheil Bochum, Medical Clinic II Ruhr University Bochum Germany

Assem Aweimer

Department of Cardiology and Angiology Bergmannsheil Bochum, Medical Clinic II Ruhr University Bochum Germany

Xuehui Fan

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Sebastian Diecke

Max Delbrück Center for Molecular Medicine Berlin Germany

Ibrahim Akin

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany

Guang Li

Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province Institute of Cardiovascular Research, Southwest Medical University Luzhou China

Xiaobo Zhou

First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg Mannheim Germany