Craft-and-Stick Xurographic Manufacturing of Integrated Microfluidic Electrochemical Sensing Platform
Supatinee Kongkaew,
Lingyin Meng,
Warakorn Limbut,
Guozhen Liu,
Proespichaya Kanatharana,
Panote Thavarungkul,
Wing Cheung Mak
Affiliations
Supatinee Kongkaew
Biosensors and Bioelectronics Centre, Division of Sensor and Actuator Systems, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping, Sweden
Lingyin Meng
Biosensors and Bioelectronics Centre, Division of Sensor and Actuator Systems, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping, Sweden
Warakorn Limbut
Center of Excellence for Trace Analysis and Biosensor, Prince of Songkla University, Hat Yai 90112, Songkhla, Thailand
Guozhen Liu
School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China
Proespichaya Kanatharana
Center of Excellence for Trace Analysis and Biosensor, Prince of Songkla University, Hat Yai 90112, Songkhla, Thailand
Panote Thavarungkul
Center of Excellence for Trace Analysis and Biosensor, Prince of Songkla University, Hat Yai 90112, Songkhla, Thailand
Wing Cheung Mak
Biosensors and Bioelectronics Centre, Division of Sensor and Actuator Systems, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping, Sweden
An innovative modular approach for facile design and construction of flexible microfluidic biosensor platforms based on a dry manufacturing “craft-and-stick” approach is developed. The design and fabrication of the flexible graphene paper electrode (GPE) unit and polyethylene tetraphthalate sheet (PET)6/adhesive fluidic unit are completed by an economic and generic xurographic craft approach. The GPE widths and the microfluidic channels can be constructed down to 300 μm and 200 μm, respectively. Both units were assembled by simple double-sided adhesive tapes into a microfluidic integrated GPE (MF-iGPE) that are flexible, thin (−1 glucose. The MF-iGPE showed good reproducibility for glucose detection (RSD n = 6) and required only 10 μL of the analyte. This modular craft-and-stick manufacturing approach could potentially further develop along the concept of paper-crafted model assembly kits suitable for low-resource laboratories or classroom settings.
