Nature Communications (Apr 2019)
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
- Hoi Leong Xavier Wong,
- Hong-yan Qin,
- Siu Wai Tsang,
- Xiao Zuo,
- Sijia Che,
- Chi Fung Willis Chow,
- Xi Li,
- Hai-tao Xiao,
- Ling Zhao,
- Tao Huang,
- Cheng Yuan Lin,
- Hiu Yee Kwan,
- Tao Yang,
- Frank M. Longo,
- Aiping Lyu,
- Zhao-xiang Bian
Affiliations
- Hoi Leong Xavier Wong
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- Hong-yan Qin
- Department of Pharmacy, First Hospital of Lanzhou University
- Siu Wai Tsang
- School of Chinese Medicine, Hong Kong Baptist University
- Xiao Zuo
- School of Pharmacy, Lanzhou University
- Sijia Che
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- Chi Fung Willis Chow
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- Xi Li
- Department of Gastroenterology, Peking University Shenzhen Hospital
- Hai-tao Xiao
- School of Pharmaceutical Sciences, Health Science Center, Shenzhen University
- Ling Zhao
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- Tao Huang
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- Cheng Yuan Lin
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- Hiu Yee Kwan
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- Tao Yang
- Department of Neurology and Neurological Sciences, Stanford University School of Medicine
- Frank M. Longo
- Department of Neurology and Neurological Sciences, Stanford University School of Medicine
- Aiping Lyu
- School of Chinese Medicine, Hong Kong Baptist University
- Zhao-xiang Bian
- Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University
- DOI
- https://doi.org/10.1038/s41467-019-09744-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Early life stress has been associated with the occurrence of gastrointestinal diseases later in life, but underlying mechanisms remain poorly understood. Here, Wong et al. show that early life stress leads to expansion of intestinal stem cells and their differentiation into serotonin-producing enterochromaffin cells through crosstalk between NGF and Wnt signalling pathways.
