npj Parkinson's Disease (Mar 2023)
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data
- Hampton L. Leonard,
- Ruqaya Murtadha,
- Alejandro Martinez-Carrasco,
- Alina Jama,
- Amica Corda Müller-Nedebock,
- Ana-Luisa Gil-Martinez,
- Anastasia Illarionova,
- Anni Moore,
- Bernabe I. Bustos,
- Bharati Jadhav,
- Brook Huxford,
- Catherine Storm,
- Clodagh Towns,
- Dan Vitale,
- Devina Chetty,
- Eric Yu,
- Francis P. Grenn,
- Gabriela Salazar,
- Geoffrey Rateau,
- Hirotaka Iwaki,
- Inas Elsayed,
- Isabelle Francesca Foote,
- Zuné Jansen van Rensburg,
- Jonggeol Jeff Kim,
- Jie Yuan,
- Julie Lake,
- Kajsa Brolin,
- Konstantin Senkevich,
- Lesley Wu,
- Manuela M. X. Tan,
- María Teresa Periñán,
- Mary B. Makarious,
- Michael Ta,
- Nikita Simone Pillay,
- Oswaldo Lorenzo Betancor,
- Paula R. Reyes-Pérez,
- Pilar Alvarez Jerez,
- Prabhjyot Saini,
- Rami al-Ouran,
- Ramiya Sivakumar,
- Raquel Real,
- Regina H. Reynolds,
- Ruifneg Hu,
- Shameemah Abrahams,
- Shilpa C. Rao,
- Tarek Antar,
- Thiago Peixoto Leal,
- Vassilena Iankova,
- William J. Scotton,
- Yeajin Song,
- Andrew Singleton,
- Mike A. Nalls,
- Sumit Dey,
- Sara Bandres-Ciga,
- Cornelis Blauwendraat,
- Alastair J. Noyce,
- on behalf of The International Parkinson Disease Genomics Consortium (IPDGC) and The Global Parkinson’s Genetics Program (GP2)
Affiliations
- Hampton L. Leonard
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Ruqaya Murtadha
- Center for Alzheimer’s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Alejandro Martinez-Carrasco
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London
- Alina Jama
- Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London
- Amica Corda Müller-Nedebock
- Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University
- Ana-Luisa Gil-Martinez
- Department of Neurodegenerative Disease, University College London
- Anastasia Illarionova
- German Center for Neurodegenerative Diseases (DZNE)
- Anni Moore
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Bernabe I. Bustos
- The Ken & Ruth Davee Department of Neurology and Simpson Querrey Center of Neurogenetics, Feinberg Feinberg School of Medicine, Northwestern University
- Bharati Jadhav
- Department of Genetics and Genomic Sciences and Mindich Child Health and Development Institute, Icahn School of Medicine at Mount, Hess Center for Science and Medicine
- Brook Huxford
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London
- Catherine Storm
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London
- Clodagh Towns
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London
- Dan Vitale
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Devina Chetty
- Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London
- Eric Yu
- Department of Human Genetics, McGill University
- Francis P. Grenn
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Gabriela Salazar
- INNCOSYS, Col. Morelos Second Section
- Geoffrey Rateau
- Institut du Cerveau - Institute of Brain and Spine (ICM), Hôpital Pitié, 47 Bd de l’Hôpital
- Hirotaka Iwaki
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Inas Elsayed
- Faculty of pharmacy, University of Gezira
- Isabelle Francesca Foote
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London
- Zuné Jansen van Rensburg
- Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London
- Jonggeol Jeff Kim
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Jie Yuan
- Center for Advanced Parkinson Research, Brigham and Women’s Hospital, Harvard Medical School
- Julie Lake
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Kajsa Brolin
- Translational Neurogenetics Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University
- Konstantin Senkevich
- Department of Human Genetics, McGill University
- Lesley Wu
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London
- Manuela M. X. Tan
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London
- María Teresa Periñán
- Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla
- Mary B. Makarious
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Michael Ta
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Nikita Simone Pillay
- South African National Bioinformatics Institute (SANBI), South African Medical Research Council Bioinformatics Unit, University of the Western Cape
- Oswaldo Lorenzo Betancor
- Veterans Affairs Puget Sound Health Care System
- Paula R. Reyes-Pérez
- Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de
- Pilar Alvarez Jerez
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Prabhjyot Saini
- Department of Human Genetics, McGill University
- Rami al-Ouran
- Department of Pediatrics, Baylor College of Medicine
- Ramiya Sivakumar
- University of Southern California
- Raquel Real
- Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London
- Regina H. Reynolds
- South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University
- Ruifneg Hu
- Center for Advanced Parkinson Research, Brigham and Women’s Hospital, Harvard Medical School
- Shameemah Abrahams
- Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London
- Shilpa C. Rao
- Department of Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation
- Tarek Antar
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Thiago Peixoto Leal
- Department of Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation
- Vassilena Iankova
- Department of Neurology With Friedrich Baur Institut, University Hospital of Ludwig-Maximilians-Universität München
- William J. Scotton
- South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University
- Yeajin Song
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Andrew Singleton
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Mike A. Nalls
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Sumit Dey
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London
- Sara Bandres-Ciga
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Cornelis Blauwendraat
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Alastair J. Noyce
- Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London
- on behalf of The International Parkinson Disease Genomics Consortium (IPDGC) and The Global Parkinson’s Genetics Program (GP2)
- DOI
- https://doi.org/10.1038/s41531-023-00472-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Abstract Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD.
