Epidemiologic Profile of Type-Specific Human Papillomavirus Infection after Initiation of HPV Vaccination
Masayuki Sekine,
Manako Yamaguchi,
Risa Kudo,
Sharon J. B. Hanley,
Megumi Hara,
Sosuke Adachi,
Yutaka Ueda,
Etsuko Miyagi,
Sayaka Ikeda,
Asami Yagi,
Takayuki Enomoto
Affiliations
Masayuki Sekine
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori, Chuo-ward, Niigata 951-8510, Japan
Manako Yamaguchi
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori, Chuo-ward, Niigata 951-8510, Japan
Risa Kudo
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori, Chuo-ward, Niigata 951-8510, Japan
Sharon J. B. Hanley
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
Megumi Hara
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan
Sosuke Adachi
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori, Chuo-ward, Niigata 951-8510, Japan
Yutaka Ueda
Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
Etsuko Miyagi
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan
Sayaka Ikeda
Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Asami Yagi
Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
Takayuki Enomoto
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori, Chuo-ward, Niigata 951-8510, Japan
Organized human papillomavirus vaccination (OHPV) in Japan was introduced in 2010 for girls aged 12–16 years who were born in 1994 or later. The rate of OHPV coverage was 70–80%. However, after suspension of the government vaccination recommendation, the coverage dramatically decreased. We aim to investigate the change in prevalence of HPV infection after the initiation of HPV vaccination. We recruited females aged 20–21 years attending public cervical cancer screening from 2014 to 2017 fiscal years (April 2014 to March 2018). Residual Pap test specimens were collected for HPV testing. We compared the prevalence of HPV type-specific infection between women registered in 2014 (born in 1993–1994, including the pre-OHPV generation) and registered in 2015–2017 (born in 1994–1997, the OHPV generation). We collected 2379 specimens. The vaccination coverage figures were 30.7%, 86.6%, 88.4% and 93.7% (p p = 0.02). The three most prevalent types were HPV52, 16 and 56 in 2014, and HPV52, 58 and 56 in 2015–2017, respectively. HPV16 and 33 infection rates decreased. On the other hand, the HPV58 infection rate was obviously increased after OHPV from 0.3% to 2.1%. Our study demonstrates that the prevalence of HPV16/18 infection dramatically decreased and the profile of type-specific HPV infection was changed after OHPV.