Frontiers in Human Neuroscience (Jan 2014)
Chronic traumatic encephalopathy and other neurodegenerative proteinopathies
- Maria Carmela Tartaglia,
- Maria Carmela Tartaglia,
- Maria Carmela Tartaglia,
- Lili-Naz eHazrati,
- Lili-Naz eHazrati,
- Lili-Naz eHazrati,
- Karen D Davis,
- Karen D Davis,
- Karen D Davis,
- Karen D Davis,
- Karen D Davis,
- Robin E.A. Green,
- Robin E.A. Green,
- Robin E.A. Green,
- Robin E.A. Green,
- Richard eWennberg,
- Richard eWennberg,
- David eMikulis,
- David eMikulis,
- Leo John Ezerins,
- Leo John Ezerins,
- Michelle eKeightley,
- Michelle eKeightley,
- Michelle eKeightley,
- Michelle eKeightley,
- Michelle eKeightley,
- Michelle eKeightley,
- Charles eTator,
- Charles eTator
Affiliations
- Maria Carmela Tartaglia
- University Health Network - Toronto Western Hospital, University of Toronto
- Maria Carmela Tartaglia
- University of Toronto
- Maria Carmela Tartaglia
- University Health Network
- Lili-Naz eHazrati
- University of Toronto
- Lili-Naz eHazrati
- University Health Network
- Lili-Naz eHazrati
- University of Toronto
- Karen D Davis
- University Health Network - Toronto Western Hospital , University of Toronto
- Karen D Davis
- University Health Network
- Karen D Davis
- University Health Network - Toronto Western Research Institute
- Karen D Davis
- University of Toronto
- Karen D Davis
- University of Toronto
- Robin E.A. Green
- University Health Network - Toronto Rehabilitation Institute
- Robin E.A. Green
- University Health Network
- Robin E.A. Green
- University of Toronto
- Robin E.A. Green
- University of Toronto
- Richard eWennberg
- University Health Network - Toronto Western Hospital, University of Toronto
- Richard eWennberg
- University Health Network
- David eMikulis
- Toronto Western Hospital, University of Toronto
- David eMikulis
- University Health Network
- Leo John Ezerins
- Canadian Football League Alumni Association
- Leo John Ezerins
- University Health Network
- Michelle eKeightley
- University Health Network - Toronto Rehabilitation Institute
- Michelle eKeightley
- University Health Network
- Michelle eKeightley
- Holland Bloorview Kids Rehabilitation Hospital
- Michelle eKeightley
- University of Toronto
- Michelle eKeightley
- University of Toronto
- Michelle eKeightley
- University of Toronto
- Charles eTator
- University Health Network - Toronto Western Hospital , University of Toronto
- Charles eTator
- University Health Network
- DOI
- https://doi.org/10.3389/fnhum.2014.00030
- Journal volume & issue
-
Vol. 8
Abstract
Chronic traumatic encephalopathy (CTE) is described as a slowly progressive neurodegenerative disease believed to result from multiple concussions. Traditionally, concussions were considered benign events and although most people recover fully, about 10% develop a post-concussive syndrome with persisting neurological, cognitive and neuropsychiatric symptoms. CTE was once thought to be unique to boxers, but it has now been observed in many different athletes having suffered multiple concussions as well as in military personal after repeated blast injuries. Much remains unknown about the development of CTE but its pathological substrate is usually tau, similar to that seen in Alzheimer’s disease and frontotemporal lobar degeneration. The aim of this perspective is to compare and contrast clinical and pathological CTE with the other neurodegenerative proteinopathies and highlight that there is an urgent need for understanding the relationship between concussion and the development of CTE as it may provide a window into the development of a proteinopathy and thus new avenues for treatment.
Keywords
- Frontotemporal Lobar Degeneration
- Alzheimer's disease
- neurodegenerative disease
- tau
- Concussions
- chronic traumatic encephalopathy
