Relationship of Peripheral Blood Platelet to Lymphocyte Ratio with the Severity of Coronary Disease in Patients with Acute Coronary Syndrome in Taleghani Hospital, Urmia, Iran

Abstract

Abstract Introduction: Peripheral Blood Platelet to Lymphocyte Ratio (PLR) has been recently suggested as a prognostic determinant in cardiac ischemic events, followed by mortality. The present study aimed to evaluate the predictive power of PLR in predicting the severity of coronary artery involvement in patients presented with the acute coronary syndrome. Materials & Methods: This cross-sectional study included 520 patients who were referred to Taleghani Hospital, Urmia, Iran, with the acute coronary syndrome and underwent coronary angiography. The information of patients’ coronary angiography was investigated; moreover, the severity and extent of coronary artery involvement were determined based on GENSINI criteria. Finally, the data were analyzed in SPSS software (version 21). Ethics code: IR.UMSU.REC.1393.275 Findings: There was a significant and positive correlation between PLR and coronary artery involvement based on the GENSINI criteria (P=0.005). Furthermore, according to the multivariate linear regression model, PLR was an independent predictor of the severity and coronary artery involvement according to GENSINI criteria among the patients with the acute coronary syndrome (P=0.049). Discussions & Conclusions: The PLR seems to be an independent predictor of the severity of coronary artery involvement in patients admitted with acute coronary artery disease.

Keywords

• coronary disease
• lymphocytes
• platelets
• prognosis