ANTIBODIESTOBENZO [A] PYREN, ESTRADIOL AND PROGESTERON IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS

Abstract

Objective – to study the social and household characteristics and specific immune responses to hormone-like xenobiotics and sex steroids in women with endometriosis. Materials and methods. A retrospective case-control study was conducted. The study included 200 women. Group I – women with a verified diagnosis of IEG (n = 100), Group II – women with tubal genesis infertility (n = 100). Using non-competitive enzyme immunoassay, all women in the studied groups studied serum antibodies (AT) of the IgA and IgG class specific for benzo[a]pyrene (BP), estradiol (ES) and progesterone (PG). The threshold values of antibodies associated with an increased risk of endometriosis were identified. The results. Women with endometriosis are more often subject to increased exposure to EDS, due to active and passive smoking. In patients with endometriosis, the levels of IgA and IgG antibodies to steroid hormones and benzo[a]pyrene are statistically significantly higher. Conclusion. The effects of EDS can be considered a risk factor for endometriosis.

Keywords

• эндометриоз
• ксенобиотики
• бензо[а]пирен
• эстроген
• прогестерон
• антитела