Disseminated Scedosporium apiospermum central nervous system infection after lung transplantation: A case report with successful recovery

Abstract

Scedosporium species are fungal opportunistic pathogens frequently seen in chronic lung diseases such as in cystic fibrosis (CF). They can cause a wide spectrum of diseases mainly in immunodeficient patients. Invasive, disseminated infections with poor prognosis have been described after lung transplantation. We present a CF-patient with disseminated Scedosporium apiospermum infection after lung transplantation. The patient had skin, surgical wound, spinal cord, and brain involvements. She recovered fully after prolonged course of voriconazole treatment. Keywords: Cystic fibrosis, Lung transplantation, Scedosporium apiospermum, Disseminated CNS infection, Voriconazole