Nature Communications (May 2021)
Loss of Ambra1 promotes melanoma growth and invasion
- Luca Di Leo,
- Valérie Bodemeyer,
- Francesca M. Bosisio,
- Giuseppina Claps,
- Marco Carretta,
- Salvatore Rizza,
- Fiorella Faienza,
- Alex Frias,
- Shawez Khan,
- Matteo Bordi,
- Maria P. Pacheco,
- Julie Di Martino,
- Jose J. Bravo-Cordero,
- Colin J. Daniel,
- Rosalie C. Sears,
- Marco Donia,
- Daniel H. Madsen,
- Per Guldberg,
- Giuseppe Filomeni,
- Thomas Sauter,
- Caroline Robert,
- Daniela De Zio,
- Francesco Cecconi
Affiliations
- Luca Di Leo
- Melanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Valérie Bodemeyer
- Melanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Francesca M. Bosisio
- Lab of Translational Cell and Tissue Research, University of Leuven
- Giuseppina Claps
- INSERM U981, Gustave Roussy Institute
- Marco Carretta
- National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital
- Salvatore Rizza
- Redox Biology Group, Danish Cancer Society Research Center
- Fiorella Faienza
- Department of Biology, University of Rome Tor Vergata
- Alex Frias
- Melanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Shawez Khan
- National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital
- Matteo Bordi
- Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital
- Maria P. Pacheco
- Life Sciences Research Unit, University of Luxembourg
- Julie Di Martino
- School of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Jose J. Bravo-Cordero
- School of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Colin J. Daniel
- Department of Molecular and Medical Genetics, Oregon Health & Science University
- Rosalie C. Sears
- Department of Molecular and Medical Genetics, Oregon Health & Science University
- Marco Donia
- National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital
- Daniel H. Madsen
- National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital
- Per Guldberg
- Molecular Diagnostics Group, Danish Cancer Society Research Center
- Giuseppe Filomeni
- Redox Biology Group, Danish Cancer Society Research Center
- Thomas Sauter
- Life Sciences Research Unit, University of Luxembourg
- Caroline Robert
- INSERM U981, Gustave Roussy Institute
- Daniela De Zio
- Melanoma Research Team, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Francesco Cecconi
- Department of Biology, University of Rome Tor Vergata
- DOI
- https://doi.org/10.1038/s41467-021-22772-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.
