In situ monitoring of molecular aggregation using circular dichroism

Haoke Zhang; Xiaoyan Zheng; Ryan T. K. Kwok; Jia Wang; Nelson L. C. Leung; Lin Shi; Jing Zhi Sun; Zhiyong Tang; Jacky W. Y. Lam; Anjun Qin; Ben Zhong Tang

doi:10.1038/s41467-018-07299-3

Nature Communications (Nov 2018)

In situ monitoring of molecular aggregation using circular dichroism

Haoke Zhang,
Xiaoyan Zheng,
Ryan T. K. Kwok,
Jia Wang,
Nelson L. C. Leung,
Lin Shi,
Jing Zhi Sun,
Zhiyong Tang,
Jacky W. Y. Lam,
Anjun Qin,
Ben Zhong Tang

Affiliations

Haoke Zhang: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Xiaoyan Zheng: Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Beijing Institute of Technology
Ryan T. K. Kwok: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay
Jia Wang: Center for Aggregation-Induced Emission, SCUT-HKUST Joint Research Institute, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology
Nelson L. C. Leung: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay
Lin Shi: Laboratory for Nanosystem and Hierarchy Fabrication, National Center for Nanoscience and Technology
Jing Zhi Sun: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Zhiyong Tang: Laboratory for Nanosystem and Hierarchy Fabrication, National Center for Nanoscience and Technology
Jacky W. Y. Lam: Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay
Anjun Qin: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Ben Zhong Tang: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University

DOI: https://doi.org/10.1038/s41467-018-07299-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Molecular aggregation is a widespread and important process in physiological metabolism, but details regarding conformational changes during the process are hard to probe. Here, the authors use circular dichroism to monitor in-situ the conformational changes occurring during molecular aggregation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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