Advances on the calcium channel TRPV6 and associated diseases

Abstract

Transient receptor potential channel subfamily V member 6 (TRPV6) , is a highly selective channel for calcium and is expressed in various tissues where it has a role in importing calcium ion through the apical membrane and plays an important role in calcium homeostasis. The functional abnormalities of TRPV6 impact calcium homeostasis, leading to several diseases including the dysplasia of fetal skeleton and transient neonatal hyperparathyroidism, bone and cartilage metabolism abnormalities, renal calcium stone formation and hypercalciuria, inflammatory bowel disease and chronic pancreatitis, et al. Recent studies have demonstrated that the overexpression of TRPV6 is also associated with high invasiveness of numerous malignancies, thus TRPV6 has the potential to be used as tumor detecting marker and therapeutic target. This review will focus on TRPV6 and its rolein associated diseases to provide evidences for the clinical translation of TRPV6 as a drug target.

Keywords

• calcium channel
• transient receptor potential channel subfamily v member 6 (trpv6)
• mutation
• diseases