Clinical, Cosmetic and Investigational Dermatology (Jun 2023)
Successful Treatment of Psoriasis Combined with Bullous Pemphigoid with Dupilumab: A Case Report
Abstract
Jing-Hua Liu,1,2 Qian Gao,1 Wen-Yi Ma,1 Zi-Lin Cheng,1 Na-Na Luo,1 Ping-Sheng Hao1 1Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Dalian Dermatosis Hospital, Dalian, Liaoning, People’s Republic of ChinaCorrespondence: Ping-Sheng Hao, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, Sichuan Province, People’s Republic of China, Tel +86-13881965024, Fax +86-28-87732407, Email [email protected]: Psoriasis is an immune-mediated chronic inflammatory disease that can be combined with complications such as diabetes, cardiovascular disease, obesity, and kidney disease. The comorbidity of psoriasis with autoimmune bullous diseases (AIBD) has been reported previously in several cases, the most frequent of which is bullous pemphigoid (BP). The underlying mechanisms of psoriasis with BP are not clear and there are no uniform treatment criteria. Based on previous case reports, the coexistence of psoriasis and BP may be related to inflammatory activity, medications, phototherapy, and infection. We report a case of a psoriasis patient who developed BP after taking Chinese herbal compounds and was successfully treated with dupilumab, which is the first reported case of applying dupilumab to treat psoriasis with BP comorbidities.Keywords: autoimmune bullous diseases, dupilumab, biologics, comorbidity, Chinese herbal compounds
