PLoS Neglected Tropical Diseases (Oct 2019)

A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.

  • Sunniva Todnem Sakkestad,
  • Hans Steinsland,
  • Steinar Skrede,
  • Kristine Lillebø,
  • Dag Harald Skutlaberg,
  • Anne Berit Guttormsen,
  • Anton Zavialov,
  • Sari Paavilainen,
  • Hanne Søyland,
  • Marianne Sævik,
  • Astrid Rykkje Heien,
  • Marit Gjerde Tellevik,
  • Eileen Barry,
  • Nina Langeland,
  • Halvor Sommerfelt,
  • Kurt Hanevik

DOI
https://doi.org/10.1371/journal.pntd.0007823
Journal volume & issue
Vol. 13, no. 10
p. e0007823

Abstract

Read online

Trial registrationClinicalTrials.gov ClinicalTrials.gov, Project ID: NCT02870751.