Upconversion nanoparticles@AgBiS2 core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers

Zhaoyou Chu; Tian Tian; Zhenchao Tao; Juan Yang; Benjin Chen; Hao Chen; Wanni Wang; Peiqun Yin; Xiaoping Xia; Hua Wang; Haisheng Qian

Bioactive Materials (Nov 2022)

Upconversion nanoparticles@AgBiS2 core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers

Zhaoyou Chu,
Tian Tian,
Zhenchao Tao,
Juan Yang,
Benjin Chen,
Hao Chen,
Wanni Wang,
Peiqun Yin,
Xiaoping Xia,
Hua Wang,
Haisheng Qian

Affiliations

Zhaoyou Chu: School of Biomedical Engineering, School of Basic Medical Sciences, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, PR China
Tian Tian: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, 230032, PR China
Zhenchao Tao: Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, China
Juan Yang: School of Biomedical Engineering, School of Basic Medical Sciences, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, PR China
Benjin Chen: School of Biomedical Engineering, School of Basic Medical Sciences, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, PR China
Hao Chen: School of Biomedical Engineering, School of Basic Medical Sciences, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, PR China
Wanni Wang: School of Biomedical Engineering, School of Basic Medical Sciences, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, PR China
Peiqun Yin: School of Biomedical Engineering, School of Basic Medical Sciences, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, PR China
Xiaoping Xia: Department of Obstetrics and Gynecology, Children's Hospital of Anhui Medical University, Anhui Provincial Children's Hospital, Hefei, Anhui, 230051, PR China; Corresponding author.
Hua Wang: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, 230032, PR China; Corresponding author.
Haisheng Qian: School of Biomedical Engineering, School of Basic Medical Sciences, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, 230032, PR China; Corresponding author.

Journal volume & issue: Vol. 17
pp. 71 – 80

Abstract

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UCNPs@AgBiS2 core-shell nanoparticles that AgBiS2 coated on the surface of upconversion nanoparticles (UCNPs) was successfully prepared through an ion exchange reaction. The photothermal conversion efficiency of AgBiS2 can be improved from 14.7% to 45% due to the cross relaxation between Nd ions and AgBiS2. The doping concentration of Nd ions played a critical role in the production of reactive oxygen species (ROS) and enhanced the photothermal conversion efficiency. The NaYF4:Yb/Er/Nd@NaYF4:Nd nanoparticles endows strong upconversion emissions when the doped concentration of Nd ions is 1% in the inner core, which excites the AgBiS2 shell to produce ROS for photodynamic therapy (PDT) of cancer cells. As a result, the as-prepared NaYF4:Yb/Er/Nd@NaYF4:Nd@AgBiS2 core-shell nanoparticles showed combined photothermal/photodynamic therapy (PTT/PDT) against malignant tumors. This work provides an alternative near-infrared light-active multimodal nanostructures for applications such as fighting against cancers.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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