The side effect profile of nonsteroidal anti-inflammatory drugs for rheumatic

Abstract

Objective: to study the side effect profile of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rheumatic diseases (RD). Subjects and methods. The study enrolled 373 patients (301 women and 72 men) with RD, the mean age of whom was 58.9±1.3 years; the duration of the disease was 6.1±0.7 years. This study was cross-sectional and randomized, by applying a questionnaire for the estimation of the NSAID side effect profile, developed at the Research Institute of Rheumatology, Russian Academy of Medical Sciences. Results and discussion. NSAIDs are an effective agent for the symptomatic treatment of pain and inflammation in most RDs. More than 50% of the patients with RD reported unpleasant sensations in the digestive system. Dyspepsia was present in the absolute majority of RD patients (77.7% of the patients with rheumatoid arthritis; 100% of those with ankylosing spondylitis; 47.8% of those with osteoarthosis) who had taken for more than a year

Keywords

• rheumatic diseases
• nonsteroidal anti-inflammatory drugs
• side effects
• meloxicam