Signal amplification for sumatriptan sensing based on polymeric surface decorated with Cu nanoparticles

Abstract

A new nanocomposite, Cu NPs/poly-melamine, was deposited on a glassy carbon electrode by cyclic voltammetry. The uniform deposition of the nanocomposite was observed by the field emission scanning electron microscopy. The electron transfer characteristics of the drug sumatriptan (SUM), was greatly improved on the modified electrode. The prepared electrode was used for the sensitive determination of SUM by the differential pulse voltammetry. Linear calibration curve was obtained in the concentration ranges of 0.08–0.58 and 0.58–6.5 μM, and the detection limit of 0.025 μM. The proposed method was evaluated by the determination of SUM in human biological fluids such as urine and blood plasma with satisfactory results (recovery > 99 %).

Keywords

• sumatriptan
• melamine
• glassy carbon electrode
• copper nanoparticles
• differential pulse voltammetry