Nature Communications (Jun 2020)

Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition

  • Jennifer E. Dawson,
  • Alaji Bah,
  • Zhenfu Zhang,
  • Robert M. Vernon,
  • Hong Lin,
  • P. Andrew Chong,
  • Manasvi Vanama,
  • Nahum Sonenberg,
  • Claudiu C. Gradinaru,
  • Julie D. Forman-Kay

DOI
https://doi.org/10.1038/s41467-020-16783-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

Read online

Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to an eIF4E binding-incompatible state to control translation.