Mice as Animal Model for Evaluation of Therapeutic Efficacy of Preparations against Monkeypox

Abstract

of MPV after 7 days postinfection, applying peroral administration once within 24 hours (24 hours before infection and 7 days after infection of mouse with 60 µg/g of a preparation). Displayed is the feasibility of using 8–15-days-old ICR mice (body weight 9–11 g) as an animal model for evaluation of therapeutic efficacy of the preparations under development against Monkeypox and smallpox.

Keywords

• вирус оспы обезьян
• мышь
• интраназальное инфицирование
• 50 % инфицирующая доза
• клинические признаки
• противооспенные препараты
• модельное животное
• monkeypox virus
• mouse
• intranasal infection
• 50 % infective dose
• clinical signs
• preparations against monkeypox
• animal model