Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience

Channa R. Jayasekera, MD; Holenarasipur R. Vikram, MD; Zeeshan Rifat, MBBS; Josiah Wagler, DO; Keita Okubo, MD, PhD; Brandon R. Braaksma, PA-C; Jack W. Harbell, MD; Caroline C. Jadlowiec, MD; Nitin N. Katariya, MD; Amit K. Mathur, MD; Adyr Moss, MD; K. Sudhakar Reddy, MBBS; Andrew Singer, MD, PhD; Robert Orenstein, DO; Christopher F. Saling, MD; Maria T. Seville, MD; Girish K. Mour, MD; Hugo E. Vargas, MD; Thomas J. Byrne, MD; Winston R. Hewitt, Jr, MD; Bashar A. Aqel, MD

doi:10.1097/TXD.0000000000001286

Transplantation Direct (Feb 2022)

Solid Organ Transplantation From SARS-CoV-2–infected Donors to Uninfected Recipients: A Single-center Experience

Channa R. Jayasekera, MD,
Holenarasipur R. Vikram, MD,
Zeeshan Rifat, MBBS,
Josiah Wagler, DO,
Keita Okubo, MD, PhD,
Brandon R. Braaksma, PA-C,
Jack W. Harbell, MD,
Caroline C. Jadlowiec, MD,
Nitin N. Katariya, MD,
Amit K. Mathur, MD,
Adyr Moss, MD,
K. Sudhakar Reddy, MBBS,
Andrew Singer, MD, PhD,
Robert Orenstein, DO,
Christopher F. Saling, MD,
Maria T. Seville, MD,
Girish K. Mour, MD,
Hugo E. Vargas, MD,
Thomas J. Byrne, MD,
Winston R. Hewitt, Jr, MD,
Bashar A. Aqel, MD

Affiliations

Channa R. Jayasekera, MD: 1 Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Holenarasipur R. Vikram, MD: 2 Division of Infectious Diseases, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Zeeshan Rifat, MBBS: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Josiah Wagler, DO: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Keita Okubo, MD, PhD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Brandon R. Braaksma, PA-C: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Jack W. Harbell, MD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Caroline C. Jadlowiec, MD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Nitin N. Katariya, MD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Amit K. Mathur, MD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Adyr Moss, MD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
K. Sudhakar Reddy, MBBS: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Andrew Singer, MD, PhD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Robert Orenstein, DO: 2 Division of Infectious Diseases, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Christopher F. Saling, MD: 2 Division of Infectious Diseases, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Maria T. Seville, MD: 2 Division of Infectious Diseases, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Girish K. Mour, MD: 4 Division of Nephrology, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Hugo E. Vargas, MD: 1 Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Thomas J. Byrne, MD: 1 Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.
Winston R. Hewitt, Jr, MD: 3 Division of Transplant Surgery, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
Bashar A. Aqel, MD: 1 Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ.

DOI: https://doi.org/10.1097/TXD.0000000000001286
Journal volume & issue: Vol. 8, no. 2
p. e1286

Abstract

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Background. The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission. Methods. Abdominal solid organs from SARS-CoV-2–infected donors were transplanted into uninfected recipients. Results. Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2–infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA. Conclusions. Transplanting nonlung organs from SARS-CoV-2–infected donors into uninfected recipients demonstrated no evidence of virus transmission.

Published in Transplantation Direct

ISSN: 2373-8731 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: http://journals.lww.com/transplantationdirect/Pages/default.aspx

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