Data on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells
Alexey V. Solomonov,
Yuriy S. Marfin,
Evgeniy V. Rumyantsev,
Elena Ragozin,
Talia Shekhter Zahavi,
Gary Gellerman,
Alexander B. Tesler,
Falk Muench,
Akiko Kumagai,
Atsushi Miyawaki
Affiliations
Alexey V. Solomonov
Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskij prosp., 153000, Ivanovo, Russian; Corresponding author.
Yuriy S. Marfin
Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskij prosp., 153000, Ivanovo, Russian
Evgeniy V. Rumyantsev
Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskij prosp., 153000, Ivanovo, Russian; Ivanovo State Polytechnical University, 21 Sheremetevskij prosp., 153000, Ivanovo, Russian
Elena Ragozin
Department of Chemical Sciences, Ariel University of Samaria, Ariel, Israel
Talia Shekhter Zahavi
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel
Gary Gellerman
Department of Chemical Sciences, Ariel University of Samaria, Ariel, Israel
Alexander B. Tesler
Department of Materials and Interfaces, Faculty of Chemistry, Weizmann Institute of Science, 76100, 234 Herzl Street, Rehovot, Israel
Falk Muench
Department of Materials and Earth Sciences, Technische Universität Darmstadt, Alarich-Weiss-Strasse 2, 64287, Darmstadt, Germany
Akiko Kumagai
Centre of Brain Science, Laboratory for Cell Function and Dynamics, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan
Atsushi Miyawaki
Centre of Brain Science, Laboratory for Cell Function and Dynamics, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan
The data presented here refer to a research article entitled “Self-Assembled Micellar Clusters Based on Triton-X-family Surfactants for Enhanced Solubilization, Encapsulation, Proteins Permeability Control, and Anticancer Drug Delivery” Solomonov et al., 2019. The present article provides the General Procedure for clusterization of Triton-X-based micelles and the effect of (i) metal ion, surfactant, and chelator concentration on the developed clusters formation, (ii) surfactant-chelator relation change, (iii) metal ion-micelles concertation ratio variation, (iv) metal ion replacement, (v) solvent replacement, (vi) kinetics of clusters formation, (vii) hydrophobic fluorescent dye (Coumarin 6) solubilization in aqueous MCs media, (viii) novel anticancer peptidyl drug synthesis and characterization and (ix) the viability of HeLa cells with and without the presence of drug-free Triton-X-based family MCs. These data provide additional insights useful for understanding all aspects of the micellar clusters formation, optimization, and control. Keywords: Micellar clusters, Surfactants, Triton-X, Self-assembly, Encapsulation, Anticancer drug synthesis, Fluorescence enhancement
