Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

Lenan Zhuang; Younghoon Jang; Young-Kwon Park; Ji-Eun Lee; Shalini Jain; Eugene Froimchuk; Aaron Broun; Chengyu Liu; Oksana Gavrilova; Kai Ge

doi:10.1038/s41467-018-04127-6

Nature Communications (May 2018)

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function

Lenan Zhuang,
Younghoon Jang,
Young-Kwon Park,
Ji-Eun Lee,
Shalini Jain,
Eugene Froimchuk,
Aaron Broun,
Chengyu Liu,
Oksana Gavrilova,
Kai Ge

Affiliations

Lenan Zhuang: Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Younghoon Jang: Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Young-Kwon Park: Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Ji-Eun Lee: Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Shalini Jain: Mouse Metabolism Core Laboratory, National Institute of Diabetes, Digestive and Kidney Diseases, NIH
Eugene Froimchuk: Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Aaron Broun: Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
Chengyu Liu: Transgenic Core, National Heart, Lung, and Blood Institute, NIH
Oksana Gavrilova: Mouse Metabolism Core Laboratory, National Institute of Diabetes, Digestive and Kidney Diseases, NIH
Kai Ge: Adipocyte Biology and Gene Regulation Section, LERB, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

DOI: https://doi.org/10.1038/s41467-018-04127-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs adipogenesis by increasing H3K27me3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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