Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling

Mario Niepel; Marc Hafner; Qiaonan Duan; Zichen Wang; Evan O. Paull; Mirra Chung; Xiaodong Lu; Joshua M. Stuart; Todd R. Golub; Aravind Subramanian; Avi Ma’ayan; Peter K. Sorger

doi:10.1038/s41467-017-01383-w

Nature Communications (Oct 2017)

Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling

Mario Niepel,
Marc Hafner,
Qiaonan Duan,
Zichen Wang,
Evan O. Paull,
Mirra Chung,
Xiaodong Lu,
Joshua M. Stuart,
Todd R. Golub,
Aravind Subramanian,
Avi Ma’ayan,
Peter K. Sorger

Affiliations

Mario Niepel: HMS LINCS Center, Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School
Marc Hafner: HMS LINCS Center, Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School
Qiaonan Duan: Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai
Zichen Wang: Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai
Evan O. Paull: UC Santa Cruz Genomics Institute, University of California
Mirra Chung: HMS LINCS Center, Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School
Xiaodong Lu: Broad Institute of MIT and Harvard University
Joshua M. Stuart: UC Santa Cruz Genomics Institute, University of California
Todd R. Golub: Broad Institute of MIT and Harvard University
Aravind Subramanian: Broad Institute of MIT and Harvard University
Avi Ma’ayan: Department of Pharmacological Sciences, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai
Peter K. Sorger: HMS LINCS Center, Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-017-01383-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Understanding why some tumor cells respond to therapy and others do not is essential for advancing precision cancer care. Here, the authors perform large-scale transcriptomic profiling of breast cancer cell lines treated with anti-cancer drugs and find that certain drug classes induce cell line specific responses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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