Communications Biology (Jul 2022)
Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma
- Yewen Shi,
- Tongxin Xie,
- Bingbing Wang,
- Rong Wang,
- Yu Cai,
- Bo Yuan,
- Frederico O. Gleber-Netto,
- Xiangjun Tian,
- Alanis E. Rodriguez-Rosario,
- Abdullah A. Osman,
- Jing Wang,
- Curtis R. Pickering,
- Xiaoyong Ren,
- Andrew G. Sikora,
- Jeffrey N. Myers,
- Roberto Rangel
Affiliations
- Yewen Shi
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Tongxin Xie
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Bingbing Wang
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Rong Wang
- Department of Endodontics, School & Hospital of Stomatology, Wuhan University
- Yu Cai
- Department of Oral & Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University
- Bo Yuan
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Frederico O. Gleber-Netto
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Xiangjun Tian
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Alanis E. Rodriguez-Rosario
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Abdullah A. Osman
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Jing Wang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Curtis R. Pickering
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Xiaoyong Ren
- Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University
- Andrew G. Sikora
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Jeffrey N. Myers
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- Roberto Rangel
- Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s42003-022-03675-4
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
Oral squamous cell carcinoma models are presented with defined Trp53 mutations associated with immune checkpoint inhibitor responsiveness, e.g. T122N amino acid change of Tp53 promotes a cold TME enriched with immunosuppressive M2 macrophages resistant to ICI therapy.
