An efficient, green and micellar catalyzed preparative-scale synthesis of 3,4-Disubstituted isoxazole-5(4H)-ones in the water

Abstract

The one-pot three-component synthesis of 3,4-Disubstituted isoxazole-5(4H)-ones has been developed using an aqueous micellar medium as a catalyst under milder reaction conditions. The reaction was completed by using 25 mol% of sodium lauryl sulfate in an aqueous medium at room temperature. The reaction employs a green solvent, an eco-friendly reagent, and a non-chromatographic method for purification. The present reaction tolerates several substituted aldehydes and has proved to be efficient along with excellent yield. Moreover, the micellar catalyst was recovered and reused several times without significantly losing its catalytic activity.

Keywords

• 3
• 4-Disubstituted isoxazole-5(4 H)-ones
• Micellar catalysis
• Sodium lauryl sulphate
• Benzaldehyde