The Protein-Protein Interaction of Parkinson’s disease Associated Pin-1 Gene by using STRING’s Network.

Abstract

Parkinson’s disease is the next frequent neurodegenerative disorder after Alzheimer’s, caused primarily by the loss of dopaminergic neurons of the Substantia Nigra. Mutations in the Putative-induced Kinase - a mitochondrial Serine/Threonine-protein Kinase encoded by the PINK1 gene have been found in families with recessive early-onset Parkinson’s disease. The present study represents the protein-protein interaction of PINK1 gene which is mutated in some forms of Parkinson’s disease by using advanced Bioinformatics tools such as STRING’s Network and BIOGRID data base. In conclusion, Protein-protein interaction networks are an important ingredient for the systemlevel understanding of cellular processes such, networks can be used for assessing functional genomics data, providing an intuitive platform for annotating evolutionary properties of proteins and their structural and functional features.

Keywords

• PINK-1, Parkinson’s disease
• Protein-protein interaction
• STRING’s network