Formation of Hydroxyapatite-Based Hybrid Materials in the Presence of Platelet-Poor Plasma Additive
Ilya E. Glazov,
Valentina K. Krut’ko,
Tatiana V. Safronova,
Nikita A. Sazhnev,
Natalia R. Kil’deeva,
Roman A. Vlasov,
Olga N. Musskaya,
Anatoly I. Kulak
Affiliations
Ilya E. Glazov
Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, Surganova Str., 9/1, 220012 Minsk, Belarus
Valentina K. Krut’ko
Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, Surganova Str., 9/1, 220012 Minsk, Belarus
Tatiana V. Safronova
Department of Chemistry, Lomonosov Moscow State University, Building, 3, Leninskie Gory, 1, 119991 Moscow, Russia
Nikita A. Sazhnev
Department of Chemistry and Technology of Polymer Materials and Nanocomposites, Kosygin Russian State University, Malaya Kaluzhskaya, 1, 119071 Moscow, Russia
Natalia R. Kil’deeva
Department of Chemistry and Technology of Polymer Materials and Nanocomposites, Kosygin Russian State University, Malaya Kaluzhskaya, 1, 119071 Moscow, Russia
Roman A. Vlasov
Medical Center “Lode”, Gikalo Str., 1, 220005 Minsk, Belarus
Olga N. Musskaya
Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, Surganova Str., 9/1, 220012 Minsk, Belarus
Anatoly I. Kulak
Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, Surganova Str., 9/1, 220012 Minsk, Belarus
Biomaterials based on hydroxyapatite with controllable composition and properties are promising in the field of regenerative bone replacement. One approach to regulate the phase composition of the materials is the introduction of biopolymer-based additives into the synthesis process. The purpose of present study was to investigate the formation of hydroxyapatite-based hybrid materials in the presence of 6–24% platelet-poor plasma (PPP) additive, at a [Ca2+]/[PO43−] ratio of 1.67, pH 11, and varying maturing time from 4 to 9 days. The mineral component of the materials comprised 53% hydroxyapatite/47% amorphous calcium phosphate after 4 days of maturation and 100% hydroxyapatite after 9 days of maturation. Varying the PPP content between 6% and 24% brought about the formation of materials with rather defined contents of amorphous calcium phosphate and biopolymer component and the desired morphology, ranging from typical apatitic conglomerates to hybrid apatite-biopolymer fibers. The co-precipitated hybrid materials based on hydroxyapatite, amorphous calcium phosphate, and PPP additive exhibited increased solubility in SBF solution, which defines their applicability for repairing rhinoplastic defects.
