Palatoschisis, Schizophrenia and Hypocalcaemia: Phenotypic Expression of 22q11.2 Deletion Syndrome (DiGeorge Syndrome) in an Adult

Abstract

22q11.2 deletion syndrome typically presents with congenital cardiac anomalies, immunodeficiencies and hypoparathyroidism. However, clinical findings vary greatly. We present the case of a 56-year-old man, with a history of cleft palate and schizophrenia, who was newly diagnosed with 22q11.2 deletion syndrome during an episode of hypocalcaemia. The syndrome is caused by developmental abnormalities of the embryonic pharyngeal arch system. Treatment of hypocalcaemia with oral calcium and vitamin D is usually sufficient.

Keywords

• 22q11.2 deletion syndrome
• 22q11.2 deletion syndrome
• 22q11.2 deletion syndrome
• digeorge syndrome
• digeorge syndrome
• digeorge syndrome
• hypocalcaemia
• hypocalcaemia
• hypocalcaemia
• hypoparathyroidism
• hypoparathyroidism
• hypoparathyroidism