PLoS ONE (Jan 2010)

New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.

  • Masahiro Nakajima,
  • Atsushi Takahashi,
  • Ikuyo Kou,
  • Cristina Rodriguez-Fontenla,
  • Juan J Gomez-Reino,
  • Tatsuya Furuichi,
  • Jin Dai,
  • Akihiro Sudo,
  • Atsumasa Uchida,
  • Naoshi Fukui,
  • Michiaki Kubo,
  • Naoyuki Kamatani,
  • Tatsuhiko Tsunoda,
  • Konstantinos N Malizos,
  • Aspasia Tsezou,
  • Antonio Gonzalez,
  • Yusuke Nakamura,
  • Shiro Ikegawa

DOI
https://doi.org/10.1371/journal.pone.0009723
Journal volume & issue
Vol. 5, no. 3
p. e9723

Abstract

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Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43x10(-8) for rs7775228 and 6.73x10(-8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.