Nature Communications (Jan 2019)
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
- Min Wu,
- Yan Chang,
- Huaibin Hu,
- Rui Mu,
- Yucheng Zhang,
- Xuanhe Qin,
- Xiaotao Duan,
- Weihua Li,
- Haiqing Tu,
- Weina Zhang,
- Guang Wang,
- Qiuying Han,
- Ailing Li,
- Tao Zhou,
- Kazuhiro Iwai,
- Xuemin Zhang,
- Huiyan Li
Affiliations
- Min Wu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yan Chang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Huaibin Hu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Rui Mu
- Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yucheng Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Xuanhe Qin
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Xiaotao Duan
- State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology
- Weihua Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Haiqing Tu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Weina Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Guang Wang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Qiuying Han
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Ailing Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tao Zhou
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Kazuhiro Iwai
- Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University
- Xuemin Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Huiyan Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- DOI
- https://doi.org/10.1038/s41467-018-08043-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.
