Determination of some acute phase proteins, biochemical parameters and oxidative stress in sheep with naturally infected sheeppox virus

Abstract

The aim of the present study was to determine oxidative stress and acute phase response in naturally infected sheep with poxvirus. For this purpose, 20 poxvirus infected and 10 clinically healthy sheep were used in the study. In these animals, alkaline phosphatase (ALP), aspartate aminotransferase (AST) activity, haptoglobin, ceruloplasmin, urea, creatinine, albumin, iron (Fe), malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined. The present study determined that the concentrations of haptoglobin, ceruloplasmin, urea, creatinine, MDA and ALP, AST activity were significantly increased, and albumin, Fe and GSH concentrations were significantly decreased in the sheeppox virus infected group compared to the control group. Results of this study indicated that oxidative stress and acute phase response develop in sheep infected with poxvirus.

Keywords

• acute phase proteins
• biochemical parameters
• sheeppox